| Probing of ascorbic acid by CdS/dendrimer nanocomposites: a spectroscopic investigation. | |
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MedLine Citation:
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PMID: 20393844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gamma irradiation method has provided a route for synthesis of highly water-soluble, good-quality luminescent CdS/dendrimer nanocomposites with amino- or carboxyl-terminated PAMAM dendrimer. An attempt has been made to probe ascorbic acid with the as-synthesized CdS/dendrimer nanocomposites (DNC). Ascorbic acid (AA) is an important biological antioxidant and marker for different diseases in clinical chemistry as well as in quality control in the food industry. Micromolar concentrations of AA significantly quenched the photoluminescence (PL) of both amino (-NH(2)) and carboxylic (-COOH) functionalized semiconductor nanocomposites. The quenching followed a linear Stern-Volmer equation and time-resolved photoluminescence spectroscopy confirmed its static nature. A strong size dependence of the quenching pattern was observed. The binding constants, and the corresponding thermodynamic parameters DeltaG(theta), DeltaH(theta), DeltaS(theta) at different temperatures were calculated. CdS DNC showed selectivity towards ascorbic acid even in the presence of possible interfering molecules, such as uric acid, tartaric acid and citric acid. Nanocomposites-based assay techniques could override the complications involved in multitudes of assay procedures, providing a simple and fast new strategy for the quantification of Ascorbic acid in the range of 16.6 to 100 microM (R=0.998, n=9). The proposed method was applied to the detection of ascorbic acid in Vitamin C tablets with satisfactory results. |
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Authors:
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Srabanti Ghosh; S C Bhattacharya; Abhijit Saha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Analytical and bioanalytical chemistry Volume: 397 ISSN: 1618-2650 ISO Abbreviation: Anal Bioanal Chem Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101134327 Medline TA: Anal Bioanal Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 1573-82 Citation Subset: IM |
Affiliation:
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UGC-DAE Consortium for Scientific Research, Kolkata Centre, III/LB-8, Bidhananagar, Kolkata 700098, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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analysis* Cadmium Compounds / chemical synthesis, chemistry* Dendrimers / chemical synthesis, chemistry* Fluorescence Fluorometry* Nanostructures / chemistry* Particle Size Photochemistry Quantum Dots Semiconductors Spectrophotometry, Ultraviolet Sulfides / chemical synthesis, chemistry* Surface Properties Temperature Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Cadmium Compounds; 0/Dendrimers; 0/Sulfides; 1306-23-6/cadmium sulfide; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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