| Probable case of torsades de pointes induced by fluconazole. | |
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MedLine Citation:
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PMID: 12495173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 25-year-old woman who was hospitalized for worsening endocarditis had a prolonged QT interval at baseline and developed monomorphic ventricular arrhythmias, which were managed successfully with pacing and antiarrhythmic therapy. Several days later, the patient started receiving high-dose fluconazole for fungemia and subsequently experienced episodes of torsades de pointes, a polymorphic ventricular arrhythmia associated with a prolonged QT interval or prominent U wave on the electrocardiogram. The arrhythmia developed in the presence of known risk factors. Clinicians should be aware of these risk factors and other relevant structural similarities with drugs that cause torsades de pointes so that they can recognize patients who may be at risk for fluconazole-associated arrhythmia. |
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Authors:
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Minou Khazan; A Scott Mathis |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Pharmacotherapy Volume: 22 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-23 Completed Date: 2003-03-19 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 1632-7 Citation Subset: IM |
Affiliation:
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Pharmacy Department, Saint Barnabas Medical Center, 94 Old Short Hills Road, Livingston, NJ 07039, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Electrocardiography / drug effects Female Fluconazole / adverse effects*, chemistry, therapeutic use Humans Middle Aged Risk Factors Torsades de Pointes / chemically induced*, physiopathology |
| Chemical | |
Reg. No./Substance:
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86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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