Document Detail

Probability models and computational models for ANOVA in multicenter clinical trials.
MedLine Citation:
PMID:  12921396     Owner:  NLM     Status:  MEDLINE    
Multicenter trials are usually analyzed by fixed-effects, two-way analysis of variance. A mixed-effects computation with random treatment-by-center interaction may produce better results even if this interaction is considered truly to be a fixed effect. It may be more appropriate, however, to consider the treatment-by-center interaction to be a random effect, anyway.
Thomas Permutt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biopharmaceutical statistics     Volume:  13     ISSN:  1054-3406     ISO Abbreviation:  J Biopharm Stat     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9200436     Medline TA:  J Biopharm Stat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-505     Citation Subset:  IM    
Food and Drug Administration, Rockville, Maryland 20857, USA.
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MeSH Terms
Analysis of Variance
Mathematical Computing*
Models, Statistical*
Multicenter Studies as Topic / statistics & numerical data*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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