Document Detail

Probability of asthma based on methacholine challenge.
MedLine Citation:
PMID:  1541124     Owner:  NLM     Status:  MEDLINE    
Methacholine inhalation challenge has become an accepted test to determine the presence of airway hyperresponsiveness, a hallmark of asthma. To help physicians interpret the results of a methacholine challenge test in a clinical setting, we analyzed the test data of 1,105 subjects, asthmatics and nonasthmatics. Applying Bayes' theorem, a nomogram was constructed incorporating the prechallenge clinical diagnosis with the response to methacholine to give a posttest probability of the diagnosis of asthma. The resulting curves represent different levels of cumulative breath units at which a methacholine challenge can be considered positive. The results of a methacholine challenge test, in association with a physician's clinical assessment, can be a valuable tool in the diagnosis of asthma in those patients with an atypical history and/or physical examination.
E M Palmeiro; R J Hopp; R E Biven; A K Bewtra; N N Nair; R G Townley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  101     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  630-3     Citation Subset:  AIM; IM    
Allergic Disease Center, Creighton University, Omaha.
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MeSH Terms
Aged, 80 and over
Asthma / diagnosis*,  physiopathology
Bronchial Provocation Tests*
False Negative Reactions
False Positive Reactions
Methacholine Chloride / diagnostic use*
Middle Aged
Sensitivity and Specificity
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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