Document Detail


Probabilistic modeling of young children's overall lead exposure in France: integrated approach for various exposure media.
MedLine Citation:
PMID:  17573113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Emissions of lead into the environment (and thus its environmental concentrations) have decreased in recent years. We sought to estimate the overall lead exposure of children aged 6 months to 6 years (the population group most exposed and most sensitive to lead) in France through the various media (air, food, water, soils, and dust) and the respective contributions of each medium to the total dose. We have focused on the general population, leaving aside specific risk factors such as deteriorated lead paints. METHODS: We used the most recent French intake data for food and water, and a daily ingested quantity selected from the literature for soils and dust. Contamination data came from the first total diet study of contaminant levels in France (2000-2001), from regulatory testing of tap water (2004), a literature review of lead in urban soils, and a pilot study (2005) of lead in dust. Air quality monitoring measurements showed that the contribution of air could now be safely ignored. Weekly exposure doses were estimated with Monte Carlo simulations. RESULTS: Median weekly exposure dose was 7.5 microg/kg bw.week for children aged 6 months to 3 years and 4.7 for those aged from 3-6 years. 95th percentiles were 13.5 and 8.7 microg/kg bw.week. Exposure came mainly from food. The principal uncertainties are associated with quantification limits in food and water, representativeness and traceability of tap water samples, and absence of recent data about urban soil contamination. CONCLUSIONS: These results differ quite notably from earlier estimates and highlight the need, especially for policy-making purposes, to update exposure measurements for this metal.
Authors:
Philippe Glorennec; Nawel Bemrah; Alexandra Tard; Alban Robin; Barbara Le Bot; Denis Bard
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Publication Detail:
Type:  Journal Article     Date:  2007-06-15
Journal Detail:
Title:  Environment international     Volume:  33     ISSN:  0160-4120     ISO Abbreviation:  Environ Int     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-45     Citation Subset:  IM    
Affiliation:
National School of Public Health, Avenue du Professeur Léon Bernard, 35043 Rennes Cédex, France. philippe.glorennec@ensp.fr
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / analysis
Child
Child, Preschool
Dust / analysis
Environmental Exposure* / adverse effects
Environmental Pollutants / analysis*
France
Humans
Infant
Lead / analysis*
Lead Poisoning / prevention & control
Models, Statistical*
Risk Assessment
Soil Pollutants / analysis
Water Pollutants, Chemical / analysis
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Dust; 0/Environmental Pollutants; 0/Soil Pollutants; 0/Water Pollutants, Chemical; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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