Document Detail

Probabilistic intake assessment of multiple compounds as a tool to quantify the nutritional-toxicological conflict related to seafood consumption.
MedLine Citation:
PMID:  18155748     Owner:  NLM     Status:  MEDLINE    
Seafood represents a natural source of valuable nutrients (e.g., long chain omega-3 poly-unsaturated fatty acids (LC n-3 PUFAs), vitamin D, and iodine), but the favourable health perception is troubled by the presence of contaminants (e.g., PCBs, dioxin-like compounds, and (methyl) mercury (MeHg)). This dualism forms the basis for an important public health conflict. The objective of this study was to calculate and evaluate the simultaneous intake of multiple beneficial and harmful compounds (LC n-3 PUFAs, vitamin D, iodine, (Me)Hg, PCBs, and dioxin-like compounds) via seafood consumption in Belgium. A methodology and a software module were developed for executing probabilistic assessments of the simultaneous intake of multiple compounds leading to better insight in the problematic nature of food items involving both health benefits and risks. The simulations concerning seafood consumption in Belgium predicted that, as far as only seafood consumption is concerned, the considered populations do not reach a sufficiently high intake for the three nutrients considered (LC n-3 PUFAs, vitamin D, and iodine). Regarding the contaminants, (Me)Hg contamination of seafood on the Belgian market does not seem to be an issue of major toxicological concern. In contrast, for dioxin-like compounds the tolerable daily intake is reached by people with high seafood consumption.
Isabelle Sioen; John Van Camp; Frederik Verdonck; Wim Verbeke; Filiep Vanhonacker; Jan Willems; Stefaan De Henauw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-26
Journal Detail:
Title:  Chemosphere     Volume:  71     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-26     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1056-66     Citation Subset:  IM    
Department of Public Health, Ghent University, UZ-2 Blok A, De Pintelaan 185, B-9000 Ghent, Belgium.
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MeSH Terms
Consumer Product Safety / standards
Dioxins / analysis
Fatty Acids, Omega-3 / analysis
Food Contamination / analysis*,  prevention & control
Methylmercury Compounds / analysis
Models, Statistical*
Nutrition Policy
Polychlorinated Biphenyls / analysis
Public Health / methods*,  standards
Risk Assessment / methods
Seafood / adverse effects,  analysis*
Reg. No./Substance:
0/Dioxins; 0/Fatty Acids, Omega-3; 0/Methylmercury Compounds; 0/Polychlorinated Biphenyls

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