Document Detail

Probabilistic intake assessment and body burden estimation of dioxin-like substances in background conditions and during a short food contamination episode.
MedLine Citation:
PMID:  12113665     Owner:  NLM     Status:  MEDLINE    
The objective was to perform a dioxin body burden estimate based on a probabilistic intake assessment of PCDDs, PCDFs and dioxin-like PCBs because of the so-called 1999 'Belgian dioxin incident'. Monte Carlo simulation techniques were used to combine detailed 7-day food intake data on the individual level from a sample of 14-18-year-old adolescents with 'background' and 'incident-related' food contamination data. In background conditions, 3% of the adolescents had an intake <1 pg TEQ kg(-1) bw day(-1), while 85% had <4 pg TEQ kg(-1) bw day(-1). Milk and other dairy products were the basic source of dioxin-like contaminants, while fish constituted the main source at the higher percentiles of intake. During the dioxin incident, the estimated median dioxin intake showed a moderate increase. At the 99th percentile, the highest intake level, and the 95% upper bound uncertainty level, peak body burden-23.73 ng TEQ kg(-1) bw-remained below body burdens that in the experimental animal or in man are accompanied by a population-based observable increase in the incidence of adverse effects. The 1999 Belgian dioxin incident most likely did not affect public health in Belgium in a measurable way, although exceptions remain possible on the individual level.
B Vrijens; S De Henauw; K Dewettinck; W Talloen; L Goeyens; G De Backer; J L Willems
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives and contaminants     Volume:  19     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-12     Completed Date:  2002-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  687-700     Citation Subset:  IM    
Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium.
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MeSH Terms
Benzofurans / analysis
Body Burden
Dairy Products / analysis
Diet Surveys
Dioxins / administration & dosage*,  analysis
Fishes / metabolism
Food Contamination / analysis*
Meat / analysis
Monte Carlo Method
Polychlorinated Biphenyls / administration & dosage,  analysis
Tetrachlorodibenzodioxin / administration & dosage,  analogs & derivatives*,  analysis
Reg. No./Substance:
0/Benzofurans; 0/Dioxins; 0/Polychlorinated Biphenyls; 0/polychlorodibenzo-4-dioxin; 132-64-9/dibenzofuran; 1746-01-6/Tetrachlorodibenzodioxin

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