Document Detail

Probabilistic assessment of the cumulative dietary acute exposure of the population of Denmark to organophosphorus and carbamate pesticides.
MedLine Citation:
PMID:  19680979     Owner:  NLM     Status:  In-Process    
Organophosphorus and carbamate pesticides are acetylcholinesterase-inhibiting pesticides and as such have a common mode of action. We assessed the cumulative acute exposure of the population of Denmark to 25 organophosphorus and carbamate pesticide residues from the consumption of fruit, vegetables and cereals. The probabilistic approach was used in the assessments. Residue data obtained from the Danish monitoring programme carried out in the period 2004-2007, which included 6704 samples of fruit, vegetables and cereals, were used in the calculations. Food consumption data were obtained from the nationwide dietary survey conducted in 2000-2002. Contributions from 43 commodities were included in the calculations. We used the relative potency factor (RPF) approach to normalize the toxicity of the various organophosphorus and carbamate pesticides to the two index compounds chlorpyriphos and methamidophos. RPF values derived from the literature were used in the calculations. We calculated the cumulative acute exposure to 1.8% and 0.8% of the acute reference dose (ARfD) of 100 microg kg(-1) body weight (bw) day(-1) of chlorpyrifos as an index compound at the 99.9th percentile (P99.5) for children and adults, respectively. When we used methamidophos as the index compound, the cumulative acute intakes were calculated to 31.3% and 13.8% of the ARfD of 3 microg kg(-1) bw day(-1) at P99.9 for children and adults, respectively. With both index compounds, the greatest contributor to the cumulative acute exposure was apple. The results show that there is no cumulative acute risk for Danish consumers to acetylcholinesterase-inhibiting pesticides.
B H Jensen; A Petersen; T Christensen
Related Documents :
3061149 - When is a residue not a residue?
16944039 - Uptake and elimination of chlorpyrifos and pentachlorophenol into the freshwater amphip...
6199909 - New approaches for treatment of humans exposed to a slowly excreted environmental chemi...
12400449 - Pesticide residue analysis and its relationship to hazard characterisation (adi/arfd) a...
1393669 - Direct and correlated responses to divergent selection for residual food intake in rhod...
2475919 - Exposure of japanese quail embryos to o,p'-ddt has long-term effects on reproductive be...
21453809 - Gastrointestinal manifestations of food allergies.
12669009 - Comparing nutrient intake from food to the estimated average requirements shows middle-...
17479209 - Safe addition of vitamins and minerals to foods: setting maximum levels for fortificati...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  26     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  1038-48     Citation Subset:  IM    
Technical University of Denmark, National Food Institute, Søborg, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of post-harvest application rates of cyprodinil, treatment time and temperature on residue...
Next Document:  Antimutagenic and antigenotoxic effects of vegetable matrices on the activity of pesticides.