| Proactive maintenance therapy with a topical corticosteroid for vulvar lichen sclerosus: preliminary results of a randomized study. | |
| | |
MedLine Citation:
|
PMID: 23398459 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: the chronic and relapsing nature of vulvar lichen sclerosus (VLS) represents a challenge for its long-term management after an effective treatment with topical corticosteroids. OBJECTIVE: to assess the effectiveness of proactive, twice-weekly application of mometasone furoate 0.1% ointment, compared with daily topical vitamin E or cold cream, in keeping VLS in remission and reducing the risk of relapse after a 3-month treatment with topical corticosteroid. METHODS: 27 patients affected with VLS were enrolled into a 12-week active treatment phase (AP) with topical 0.1% mometasone furoate ointment once daily. Those who achieved disease remission entered a 52-week maintenance phase (MP) in which patients were randomized to apply either mometasone furoate 0.1% ointment twice weekly or a cold cream once daily or topical vitamin E once daily. The primary efficacy parameters were the relapse rate and the mean time of relapse. RESULTS: 25 patients considered to have been completely or almost completely healed after the AP entered the MP. By the end of the 52-week MP, 10 patients (40%) experienced a relapse: 5 in the vitamin E group (55.6%) and 5 in the cold cream group (62.5%), while no patient in the mometasone furoate 0.1% ointment group had a relapse. The occurrence of VLS relapse for patients in therapy with both vitamin E and cold cream was significantly higher than for those in proactive therapy with topical corticosteroid. The median time to relapse was the same (21.6 weeks) for the vitamin E and the emollient groups. CONCLUSIONS: once VLS has been stabilized with topical corticosteroids, twice-weekly proactive application of 0.1% mometasone furoate ointment over 56 weeks was found to be an effective and safe therapy option in maintaining VLS remission and in preventing the occurrence of relapse. |
| | |
Authors:
|
A Virgili; S Minghetti; A Borghi; M Corazza |
Related Documents
:
|
122799 - Femorofemoral grafts for unilateral occlusion of aortic bifurcation grafts. 22159929 - A randomised controlled study comparing the effects of laryngeal mask airway and endotr... 9350799 - Re-do operations after failed multisegmental reconstructive arterial surgery for critic... 8818759 - Congenital facial palsy and crossed facial nerve grafts: age and outcome. 20800429 - Treatment of perigraft seroma in expanded polytetrafluoroethylene grafts by sequential ... 8330949 - Long-term assessment of combined osseous composite grafting, root conditioning, and gui... 6655489 - Persistence of papilloedema after operation for intracranial tumour. 2369209 - Critical aortic stenosis in the first month of life: surgical results in 26 infants. 10023229 - Early treatment of a severe class ii division 1 malocclusion. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-12 |
Journal Detail:
|
Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
©The Authors BJD © 2013 British Association of Dermatologists. |
Affiliation:
|
Department of Clinical and Experimental Medicine, Section of Dermatology, University of Ferrara. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Femoral fracture repair and sciatic and femoral nerve blocks in a guinea pig.
Next Document: Risk Factors Associated with Lymphoedema among Chinese Women after Breast Cancer Surgery.