| ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra. | |
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MedLine Citation:
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PMID: 16541464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A two-dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J-resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non-linear outer loop and an inner linear least-squares fit for the concentrations. In vitro and in vivo experiments on a whole-body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N-acetylaspartate, N-acetylaspartylglutamate, choline-containing compounds, glutamate, myo-inositol, glutathione, scyllo-inositol, gamma-aminobutyric acid, alanine and ascorbic acid. |
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Authors:
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Rolf F Schulte; Peter Boesiger |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NMR in biomedicine Volume: 19 ISSN: 0952-3480 ISO Abbreviation: NMR Biomed Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-22 Completed Date: 2006-05-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 255-63 Citation Subset: IM |
Affiliation:
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Institute for Biomedical Engineering, University and ETH Zurich, CH-8092 Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms* Creatine / metabolism* Female Humans Magnetic Resonance Spectroscopy / methods* Male Nerve Tissue Proteins / metabolism* Neurotransmitter Agents / metabolism* Parietal Lobe / metabolism* Spectrum Analysis / methods Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 0/Neurotransmitter Agents; 57-00-1/Creatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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