| The Pro12Ala polymorphism in PPARgamma2 gene affects lipid parameters in Greek primary school children: A case of gene-to-gender interaction. | |
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MedLine Citation:
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PMID: 17220689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the present study we sought to evaluate the impact of the PPAR-gamma2 Pro12Ala polymorphism on blood lipid levels of primary school children. METHODS: 81 male and 92 female schoolchildren were genotyped. Biochemical, anthropometric, and lifestyle variables were assessed. RESULTS: 14.1% females and 14.8% males were heterozygotes, while the rest of the subjects were homozygotes for the Pro allele. A significant interaction between the PPARgamma-2 gene and gender on blood lipid levels was detected. In particular, Pro/Pro females exhibited higher values of total cholesterol (194 +/- 32 vs 180 +/- 28 mg/dL, P = 0.06) and triglycerides (94 +/- 31 vs 77 +/- 11 mg/dL, P = 0.045) compared to Pro/Ala individuals. The gene-to-gender interaction term was highly significant (P < 0.001). On the other hand, Pro/Pro males showed higher values of HDL cholesterol (47 +/- 8 vs 43 +/- 9 mg/dL, P = 0.001), lower total cholesterol/HDL ratio (4.04 +/- 0.59 vs 4.45 +/- 0.61, P = 0.031), lower values of apoB (59.8 +/- 11.3 vs 66.8 +/- 6.6 mg/dL, P = 0.007) and lower values of apoB/apoA1 ratio (0.41 +/- 0.09 vs 0.48 +/- 0.08, P = 0.019) compared with Pro/Ala. Even after adjusting for body mass index (BMI), total energy intake, total fat intake and saturated fat intake, differences in total cholesterol/high-density lipoprotein (HDL) cholesterol and the apoB/apoA1 ratios remained significant. Regarding females, no differences were observed among genotypes concerning total cholesterol/HDL levels (P for gene-to-gender interaction = 0.001) and the apoB/apoA1 levels (P for gene-to-gender interaction = 0.029). CONCLUSION: We show for the first time a gene-to-gender interaction on total cholesterol/HDL and apoB/apoA1 ratios, in male schoolchildren genotyped for PPAR-gamma2 Pro12Ala. |
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Authors:
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George V Z Dedoussis; Eirini V Theodoraki; Yannis Manios; Nikos Yiannakouris; Demosthenes Panagiotakos; Constantina Papoutsakis; Katerina Skenderi; Antonis Zampelas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 333 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 10-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Science in Dietetics-Nutrition, Harokopio University of Athens, Greece. dedousi@hua.gr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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chemistry,
genetics Alleles Body Mass Index Child Cohort Studies Female Greece Heterozygote Homozygote Humans Lipids / blood* Male PPAR gamma / genetics* Polymorphism, Genetic* Proline / chemistry, genetics Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/PPAR gamma; 147-85-3/Proline; 56-41-7/Alanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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