Document Detail

The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism.
MedLine Citation:
PMID:  17700648     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/OBJECTIVES: Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis. SUBJECTS/METHODS: The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma variables with insulin resistance and fasting and 2-h glucose and free fatty acid concentrations were analysed with multiple linear regression analysis. RESULTS: In men, there was a significant interaction between PPARG polymorphism and plasma docosahexaenoic acid on fasting free fatty acid concentration (P=0.036), and genotype-stratified models showed an inverse association in Pro homozygotes only (P=0.028). In women, the proportion of plasma eicosapentaenoic acid was higher in Ala-allele carriers compared to Pro homozygotes (1.67 vs 1.44% respectively, P=0.006). A significant interaction between PPARG polymorphism and fish intake on 2-h glucose was found in women (P=0.021), and genotype-stratified models suggested an inverse association in Ala-allele carriers only (P=0.039). CONCLUSIONS: The findings suggest that PPARG polymorphism might affect the plasma proportion of eicosapentaenoic acid and modulate the associations of fish intake and marine n-3 fatty acids with glucose metabolism and fasting free fatty acids.
S K Ylönen; I Salminen; V Lyssenko; S M Virtanen; L Groop; A Aro; C Saloranta;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-15
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  62     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1432-9     Citation Subset:  IM    
Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, Helsinki, Finland.
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MeSH Terms
Blood Glucose / metabolism*
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / blood*,  genetics
Diet Records
Docosahexaenoic Acids / administration & dosage,  blood
Eicosapentaenoic Acid / administration & dosage,  blood
Fatty Acids, Nonesterified / blood*
Fatty Acids, Omega-3 / administration & dosage*,  blood
Insulin / blood
Insulin Resistance / genetics
Lipids / blood
Middle Aged
PPAR gamma / genetics*
Polymorphism, Genetic*
Sex Factors
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Lipids; 0/PPAR gamma; 11061-68-0/Insulin; 147-85-3/Proline; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 56-41-7/Alanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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