Document Detail

Pro- and prebiotic supplementation induces a transient reduction in hemoglobin concentration in infants.
MedLine Citation:
PMID:  19644396     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES:: Regarding safety, we investigated the effect of prenatal probiotic and 6 months of pro- and prebiotic supplementation of infants on their hematologic values at 6 months and 2 years and factors affecting these values. PATIENTS AND METHODS:: In a prospective randomized controlled probiotic intervention trial in infants at high risk for allergy, we obtained blood samples consecutively from 98 infants at 6 months and from 658 children at 2 years to measure hematologic values. We collected fecal samples at 3 and 6 months to measure immunologic development by calprotectin, alpha-1-antitrypsin, tumor necrosis factor-alpha, and immunoglobulin A. RESULTS:: At 6 months, infants in the probiotic group had significantly lower hemoglobin (Hb) values than did the placebo group, mean (SD): 119.8 g/L (6.3) versus 123.3 g/L (8.4), P = 0.025. Adjustment for factors that might affect Hb values (breast-feeding duration, solid-food introduction, and sex), revealed no need for adjustment. A significant negative correlation emerged between Hb values at 6 months and fecal calprotectin at age 3 months r = -0.301, P = 0.009, which was affected neither by breast-feeding, sex, nor study group. At 2 years, hematologic values in both groups became similar. CONCLUSIONS:: Probiotics cause a gut mucosal inflammation with decreased Hb values during intervention, corrected after halting the supplementation.
Mikael Kuitunen; Kaarina Kukkonen; Erkki Savilahti
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  49     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  626-30     Citation Subset:  IM    
Skin and Allergy Hospital, Finland.
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MeSH Terms
Child, Preschool
Feces / chemistry
Hemoglobins / metabolism*
Leukocyte L1 Antigen Complex / metabolism*
Prenatal Care / methods*
Probiotics / adverse effects*
Prospective Studies
Reg. No./Substance:
0/Hemoglobins; 0/Leukocyte L1 Antigen Complex; 0/Prebiotics

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