| Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptin. | |
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MedLine Citation:
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PMID: 20410156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis is accelerated in people with systemic lupus erythematosus, and the presence of dysfunctional, pro-inflammatory high-density lipoproteins is a marker of increased risk. We developed a mouse model of multigenic lupus exposed to environmental factors known to accelerate atherosclerosis in humans - high-fat diet with or without injections of the adipokine leptin. BWF1 mice were the lupus-prone model; BALB/c were non-autoimmune controls. High-fat diet increased total serum cholesterol in both strains. In BALB/c mice, non-high-density lipoprotein cholesterol levels increased; they did not develop atherosclerosis. In contrast, BWF1 mice on high-fat diets developed increased quantities of high-density lipoproteins as well as elevated high-density lipoprotein scores, indicating pro-inflammatory high-density lipoproteins; they also developed atherosclerosis. In the lupus-prone strain, addition of leptin increased pro-inflammatory high-density lipoprotein scores and atherosclerosis, and accelerated proteinuria. These data suggest that environmental factors associated with obesity and metabolic syndrome can accelerate atherosclerosis and disease in a lupus-prone background. |
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Authors:
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B H Hahn; E V Lourencço; M McMahon; B Skaggs; E Le; M Anderson; N Iikuni; C K Lai; A La Cava |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-21 |
Journal Detail:
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Title: Lupus Volume: 19 ISSN: 1477-0962 ISO Abbreviation: Lupus Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-11-04 Revised Date: 2011-08-29 |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: England |
Other Details:
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Languages: eng Pagination: 913-7 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA. bhahn@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / blood, etiology, immunology*, pathology Diet Dietary Fats / immunology* Disease Models, Animal Female Humans Leptin / immunology* Lipoproteins, HDL / blood, immunology* Lupus Erythematosus, Systemic / blood, etiology, immunology*, pathology Metabolic Syndrome X / complications Mice Mice, Inbred BALB C Mice, Inbred NZB Obesity / complications Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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AI46776/AI/NIAID NIH HHS; AR53239/AR/NIAMS NIH HHS; K01 AR059095-02/AR/NIAMS NIH HHS; K23 AR053864-05/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Leptin; 0/Lipoproteins, HDL |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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