Document Detail

Pro-inflammatory cytokines of rat vasculature in DOCA-salt treatment.
MedLine Citation:
PMID:  19669669     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to ascertain the onset expression of pro-inflammatory cytokines in the aorta and kidney and establish their correlation with the increase in arterial blood pressure in rats subjected to DOCA-salt treatment. Male Sprague-Dawley rats underwent unilateral nephrectomy and received subcutaneous DOCA (20 mg/rat/week) as well as 1% NaCl and 0.2% KCl for drinking for 2 weeks. Blood pressure and expression of pro-inflammatory cytokines in aorta and kidney were studied weekly during the induction of hypertension. The treated rats exhibited a mild elevation of blood pressure at 1 week and a profound increase at 2 weeks. Quantitative RT-PCR demonstrated a 4.9-fold and a 3.6-fold enhancement in the expression of TNF-alpha and IL-6, respectively, in aorta as early as 1 week. The expression of IL-6 and TNF-alpha in the kidney remained almost unchanged at 1 week but mildly increased at 2 weeks DOCA-salt treatment. This study indicates a robust increase in the expression of IL-6 and TNF-alpha in aorta in DOCA-salt treated rats. This enhancement suggests that the activation of pro-inflammatory cytokines may contribute to onset of the elevation of blood pressure in DOCA-salt hypertension model.
Behjat Seifi; Mehri Kadkhodaee; Jie Xu; Manoocher Soleimani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-08-09
Journal Detail:
Title:  Molecular biology reports     Volume:  37     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2111-5     Citation Subset:  IM    
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, 14155-6447, Tehran, Iran.
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MeSH Terms
Aorta / drug effects,  metabolism
Blood Pressure / drug effects
Blood Vessels / drug effects*,  metabolism*
Desoxycorticosterone / pharmacology*
Gene Expression Regulation / drug effects
Inflammation Mediators / metabolism*
Interleukin-6 / genetics,  metabolism*
Kidney / drug effects,  metabolism
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Systole / drug effects
Time Factors
Tumor Necrosis Factor-alpha / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 64-85-7/Desoxycorticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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