Document Detail

Pro-inflammatory cytokines in stable chronic alcoholics: relationship with fat and lean mass.
MedLine Citation:
PMID:  17210215     Owner:  NLM     Status:  MEDLINE    
Cytokines are mediators of the inflammatory response, secreted by many tissues, including adipocytes. Chronic alcoholic liver disease and alcoholic hepatitis are associated with elevated serum cytokine levels which yield prognostic value in this situation. Most studies have been performed in patients with acute alcoholic hepatitis. However, cytokine alterations in stable alcoholics have been less studied, as is also the case for the relationship between cytokines and fat and lean mass in these patients. The aim of the present study was to analyse the relationships between some proinflammatory serum cytokine levels and lean mass, fat mass, nutritional status, and liver function parameters in stable alcoholic patients. We determined serum TNF-alpha, interleukin (IL)-6, IL-8 and TNF receptor 2 (TNFr2) in 77 male alcoholic patients in a stable phase (before hospital discharge). In all patients we performed a total-body composition analysis (Hologic DEXA), nutritional assessment including body mass index, triceps skinfold, brachial perimeter, and assessment of liver function. Forty-two healthy volunteer health workers served as controls. IL-8, TNF-alpha and TNFr2 were significantly higher in patients than in controls. No differences were observed between patients and controls regarding fat mass, but alcoholics showed significantly decreased lean mass than controls. Only IL-6 was significantly related with body fat in patients with elevated IL-6 levels. Poor relationships were observed between lean mass and cytokines; some nutritional parameters showed inverse relationships with serum TNF, whereas TNF and IL-8 were inversely related with albumin and prothrombin activity. Thus, cytokine levels were elevated in stable alcoholic patients, and IL-6 levels showed significant correlation with body fat mass, raising the possibility that adipose tissue contributes to the persistence of high levels of cytokines in stable alcoholics.
Emilio González-Reimers; Elena García-Valdecasas-Campelo; Francisco Santolaria-Fernández; María José de la Vega-Prieto; Rosa Ros-Vilamajó; Antonio Martínez-Riera; Ana Castellano-Higuera; Melchor Rodríguez-Gaspar
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Publication Detail:
Type:  Journal Article     Date:  2006-11-26
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  45     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  904-9     Citation Subset:  IM    
Servicio de Medicina Interna, Hospital Universitario, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
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MeSH Terms
Absorptiometry, Photon
Aged, 80 and over
Body Composition / immunology*
Cytokines / blood,  immunology*
Liver Diseases, Alcoholic / immunology*
Liver Function Tests
Middle Aged
Nutritional Status
Prothrombin / metabolism
Serum Albumin / metabolism
Statistics, Nonparametric
Reg. No./Substance:
0/Cytokines; 0/Serum Albumin; 9001-26-7/Prothrombin

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