Document Detail

Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders.
MedLine Citation:
PMID:  17055049     Owner:  NLM     Status:  MEDLINE    
Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1beta [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p=0.034], TNF-alpha [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p=0.041], and IFN-gamma [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p=0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.
Akira Shimada; Yasuhide Hayashi; Mizuho Ogasawara; Myoung-Ja Park; Masahiko Katoh; Hisanori Minakami; Toshiyuki Kitoh; Seiji Kojima; Keisei Kawa; Hirokazu Kimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-19
Journal Detail:
Title:  Leukemia research     Volume:  31     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-08-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1199-203     Citation Subset:  IM    
Department of Hematology/Oncology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu, Shibukawa, Gunma 377-8577, Japan.
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MeSH Terms
Child, Preschool
Cytokines / blood*
Diagnosis, Differential
Down Syndrome / blood*
Hematologic Diseases / diagnosis,  immunology*
Infant, Newborn
Leukemia, Megakaryoblastic, Acute / blood*
Myelodysplastic Syndromes / blood*
Primary Myelofibrosis / diagnosis,  immunology
Reg. No./Substance:

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