Document Detail


Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength.
MedLine Citation:
PMID:  23621451     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In mice, monocytes that exhibit a pro-inflammatory profile enter muscle tissue after muscle injury and are crucial for clearance of necrotic tissue and stimulation of muscle progenitor cell proliferation and differentiation. The aim of this study was to test if pro-inflammatory capacity of classically activated (M1) monocytes relates to muscle mass and strength in humans. This study included 191 male and 195 female subjects (mean age 64.2 years (SD 6.4) and 61.9 ±6.4 respectively) of the Leiden Longevity Study. Pro-inflammatory capacity of M1 monocytes was assessed by ex vivo stimulation of whole blood with Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS) and TLR-2/1 agonist tripalmitoyl- S-glycerylcysteine (Pam3 Cys-SK4 ), both M1 phenotype activators. Cytokines that stimulate M1 monocyte response (IFN-γ and GM-CSF) as well as cytokines that are secreted by M1 monocytes (IL-6, TNF-α, IL-12 and IL-1β) were measured. Analyses were adjusted for age, height and body fat mass. Upon stimulation with LPS, the cytokine production capacity of INF-y, GM-CSF, and TNF-α was significantly positively associated with lean body mass, appendicular lean mass and handgrip strength in men, but not in women. Upon stimulation with Pam3 Cys-SK4 , IL-6, TNF-α and Il-1β was significantly positively associated with lean body mass and appendicular lean in women, but not in men. Taken together, this study shows that higher pro-inflammatory capacity of M1 monocytes upon stimulation is associated with muscle characteristics and sex dependent. This article is protected by copyright. All rights reserved.
Authors:
K G M Beenakker; R G J Westendorp; A J M de Craen; P E Slagboom; D van Heemst; A B Maier
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-29
Journal Detail:
Title:  Aging cell     Volume:  -     ISSN:  1474-9726     ISO Abbreviation:  Aging Cell     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130839     Medline TA:  Aging Cell     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
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