| Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and -resistant acute lymphoblastic leukemia CEM cells. | |
| | |
MedLine Citation:
|
PMID: 20697841 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Although glucocorticoids (GCs) have been used to treat acute lymphoblast leukemia (ALL) for decades, the mechanisms of GC sensitivity and resistance in ALL cells are poorly understood. This study investigated the role and mechanisms of pro-apoptotic protein BIM in apoptosis of GC-sensitive and- resistant ALL cells. The dramatic apoptosis was observed in GC-sensitive CEM-C7 cells after incubated with DEX for 48 h, while not in GC-resistant CEM-C1 cells. The significant up-regulation of BIM in CEM-C7 cells induced by DEX was also observed, but no up-regulation of BIM was detected in DEX-induced CEM-C1 cells. When treated with DEX plus RU486, a glucocorticoid receptor blocker, the apoptosis and BIM expression of CEM-C7 cells were canceled. P38MAPK-blocking pharmacon SB203580 also significantly inhibited the up-regulation of BIM in CEM-C7 cells. These suggested that the absence of BIM up-regulation is one of the important mechanisms of GC resistance, GC-GR conjugation is indispensible in both GC-induced apoptosis and up-regulation of BIM, and p38 MAPK signal pathway is also involved in this process. |
| | |
Authors:
|
Ya-Ning Zhao; Xia Guo; Zhi-Gui Ma; Ling Gu; Jiao Ge; Qiang Li |
Publication Detail:
|
Type: Journal Article Date: 2010-08-10 |
Journal Detail:
|
Title: Medical oncology (Northwood, London, England) Volume: 28 ISSN: 1559-131X ISO Abbreviation: Med. Oncol. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
|
Languages: eng Pagination: 1609-17 Citation Subset: IM |
Affiliation:
|
Department of Phymatology, Baoji Municipal Central Hospital, 721008, Shaanxi, Baoji, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ATRA and anthracycline-based chemotherapy in the treatment of childhood acute promyelocytic leukemia...
Next Document: Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib.