Document Detail


Pro-apoptotic activities of novel synthetic quinones in human cancer cell lines.
MedLine Citation:
PMID:  19481864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four novel quinonoid compounds are evaluated for their apoptotic potential against three cancer cell lines, i.e. MCF-7, HeLa and MG-63. APOPercentage assay was used for the screening of the compounds and it was established that the apoptotic potential of these compounds is cell line specific. The compound 2-(1',4'-benzoquinon-2'-yl)-5-hydroxy-7-methyl-1,4-naphthoquinone (S4) was found to be most active, which has a potential to kill approximately 99% of HeLa cancer cells in vitro after 72h at a concentration of 10microM. The compound's ability to induce specific markers of apoptosis in HeLa cells is further confirmed by DNA fragmentation and cell cycle assays.
Authors:
Sunil Sagar; Ivan R Green
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-29
Journal Detail:
Title:  Cancer letters     Volume:  285     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2009-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of the Western Cape, Bellville, Cape Town, South Africa. sunil@sanbi.ac.za
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemical synthesis,  pharmacology*
Antineoplastic Agents, Phytogenic / pharmacology
Apoptosis / drug effects*
Camptothecin / pharmacology
Cell Cycle / drug effects
Cell Survival / drug effects
DNA Fragmentation
Dose-Response Relationship, Drug
Hela Cells
Humans
Neoplasms / pathology*
Quinones / chemical synthesis,  pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antineoplastic Agents, Phytogenic; 0/Quinones; 7689-03-4/Camptothecin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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