| [Pro-resolving lipid mediators in inflammatory lung diseases]. | |
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MedLine Citation:
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PMID: 21117020 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Uncontrolled inflammation of the lung contributes to the major medical and economic burden on healthcare, and the need for therapeutics to dampen pathological inflammation is largely unmet. Recently, a new genus of anti-inflammatory/ pro-resolving lipid mediators has been identified: Lipoxins, resolvins, protectins and maresins. These compounds are enzymatically derived from the polyunsaturated fatty acids (PUFAs) arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) that have long been known to have beneficial health properties. These mediators have potent anti-inflammatory effects IN VITRO and IN VIVO in murine models of lung inflammation. Therefore, this group of compounds carries considerable therapeutic potential for the treatment of many inflammatory lung diseases including asthma, cystic fibrosis and acute lung injury. |
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Authors:
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O Eickmeier; J N Hilberath; S Zielen; O Haworth |
Publication Detail:
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Type: English Abstract; Journal Article Date: 2010-11-29 |
Journal Detail:
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Title: Pneumologie (Stuttgart, Germany) Volume: 65 ISSN: 1438-8790 ISO Abbreviation: Pneumologie Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906641 Medline TA: Pneumologie Country: Germany |
Other Details:
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Languages: ger Pagination: 149-58 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Zentrum für Kinder- und Jugendmedizin, Allergologie, Pneumologie und Mukoviszidose, Klinikum der Johann Wolfgang Goethe- Universität Frankfurt a.M. olaf.eickmeier@kgu.de |
Vernacular Title:
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Die Rolle neuer "pro-resolving" Lipidmediatoren bei entzündlichen Lungenerkrankungen. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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