Document Detail

[Pro-resolving lipid mediators in inflammatory lung diseases].
MedLine Citation:
PMID:  21117020     Owner:  NLM     Status:  In-Process    
Uncontrolled inflammation of the lung contributes to the major medical and economic burden on healthcare, and the need for therapeutics to dampen pathological inflammation is largely unmet. Recently, a new genus of anti-inflammatory/ pro-resolving lipid mediators has been identified: Lipoxins, resolvins, protectins and maresins. These compounds are enzymatically derived from the polyunsaturated fatty acids (PUFAs) arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) that have long been known to have beneficial health properties. These mediators have potent anti-inflammatory effects IN VITRO and IN VIVO in murine models of lung inflammation. Therefore, this group of compounds carries considerable therapeutic potential for the treatment of many inflammatory lung diseases including asthma, cystic fibrosis and acute lung injury.
O Eickmeier; J N Hilberath; S Zielen; O Haworth
Publication Detail:
Type:  English Abstract; Journal Article     Date:  2010-11-29
Journal Detail:
Title:  Pneumologie (Stuttgart, Germany)     Volume:  65     ISSN:  1438-8790     ISO Abbreviation:  Pneumologie     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906641     Medline TA:  Pneumologie     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  149-58     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Zentrum für Kinder- und Jugendmedizin, Allergologie, Pneumologie und Mukoviszidose, Klinikum der Johann Wolfgang Goethe- Universität Frankfurt a.M.
Vernacular Title:
Die Rolle neuer "pro-resolving" Lipidmediatoren bei entzündlichen Lungenerkrankungen.
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