| Pro-inflammatory cytokines in animal and human gestation. | |
| | |
MedLine Citation:
|
PMID: 20977424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The story of cytokines in pregnancy began about 30 years ago, approximately in concomitance with the understanding that cytokines are autocrine-paracrine regulators of physiological processes. Pro-inflammatory cytokines are predominant in the early and late events of gestation, e.g. pregnancy establishment and parturition, both of which have been described as inflammatory-like events. Pro-inflammatory cytokines are also produced in response to microbes constantly in contact with the female reproductive tract. While a pro-inflammatory response is beneficial to successful pregnancy, an exaggerated response, as may occur for an unresolved infection, could result in an unfavorable pregnancy outcome in animals and humans. Therapeutic strategies are required to avoid the risks to the health of fetus and mother. In this review, we discuss the involvement of pro-inflammatory cytokines in pregnancy at implantation and parturition, including the pathologies which might be related to an alteration of the cytokine levels. We also deal with the use of anti-cytokines and/or anti-inflammatory mediators to antagonize the action of pro-inflammatory cytokines. Finally we discuss the potential of animal models to evaluate the association of cytokines in the establishment and maintenance of pregnancy. |
| | |
Authors:
|
Luana Paulesu; Jayonta Bhattacharjee; Nicoletta Bechi; Roberta Romagnoli; Silke Jantra; Francesca Ietta |
Related Documents
:
|
15692214 - Urinary neopterin levels in the different stages of pregnancy. 12180824 - Immunology of pregnancy-pregnancy as a remission inducing agent in rheumatoid arthritis. 20738264 - Effects of early conceptus signals on circulating immune cells: lessons from domestic r... 137384 - Some immunological aspects of preeclampsia. 17032794 - Synchronization of estrus and artificial insemination in replacement beef heifers using... 8411324 - Long-term prediction of birth weight. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current pharmaceutical design Volume: 16 ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2010 |
Date Detail:
|
Created Date: 2011-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 3601-15 Citation Subset: IM |
Affiliation:
|
Department of Physiology, University of Siena, Via A. Moro, 53100 Siena. Italy. paulesu@unisi.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of glucocorticoids in breast cancer.
Next Document: Use of glucocorticoids in pregnancy.