Document Detail


Pro-B-type natriuretic peptide(1-108) circulates in the general community: plasma determinants and detection of left ventricular dysfunction.
MedLine Citation:
PMID:  21414536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to investigate circulating pro-B-type natriuretic peptide (proBNP(1-108)) in the general community and evaluate its ability to detect left ventricular (LV) dysfunction.
BACKGROUND: The current concept for cardiac endocrine function is that, in response to cardiac stress, the heart secretes B-type natriuretic peptide (BNP(1-32)) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP(1-76)) after intracardiac cleavage of their molecular precursor, proBNP(1-108). We hypothesized that proBNP(1-108) circulates in normal human subjects and that it is a useful biomarker for LV dysfunction.
METHODS: Our population-based study included a cohort of 1,939 adults (age ≥45 years) from Olmsted County, Minnesota, with 672 participants defined as healthy. Subjects underwent in-depth clinical characterization, detailed echocardiography, and measurement of proBNP(1-108). Independent factors associated with proBNP(1-108) and test characteristics for the detection of LV dysfunction were determined.
RESULTS: ProBNP(1-108) in normal humans was strongly influenced by sex, age, heart rate, and body mass index. The median concentration was 20 ng/l with a mean proBNP(1-108) to NT-proBNP(1-76) ratio of 0.366, which decreased with heart failure stage. ProBNP(1-108) was a sensitive (78.8%) and specific (86.1%) biomarker for detecting LV systolic dysfunction, which was comparable to BNP(1-32), but less than NT-proBNP(1-76), in several subsets of the population.
CONCLUSIONS: ProBNP(1-108) circulates in the majority of healthy humans in the general population and is a sensitive and specific biomarker for the detection of systolic dysfunction. The proBNP(1-108) to NT-proBNP(1-76) ratio may provide insights into altered proBNP(1-108) processing during heart failure progression. Thus, this highly specific assay for proBNP(1-108) provides important new insights into the biology of the BNP system.
Authors:
Fima Macheret; Guido Boerrigter; Paul McKie; Lisa Costello-Boerrigter; Brian Lahr; Denise Heublein; Sharon Sandberg; Yasuhiro Ikeda; Alessandro Cataliotti; Kent Bailey; Richard Rodeheffer; John C Burnett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  57     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-05-19     Revised Date:  2014-02-26    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1386-95     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Area Under Curve
Biological Markers / blood*
Female
Glomerular Filtration Rate
Humans
Immunoassay / methods
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Sensitivity and Specificity
Ventricular Dysfunction, Left / diagnosis*
Grant Support
ID/Acronym/Agency:
P01 HL076611/HL/NHLBI NIH HHS; P01 HL76611/HL/NHLBI NIH HHS; R01 HL036634/HL/NHLBI NIH HHS; R01 HL36634/HL/NHLBI NIH HHS; T32 HL007111/HL/NHLBI NIH HHS; TL1 RR024152/RR/NCRR NIH HHS; TL1RR024152/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2011 Mar 22;57(12):1396-8   [PMID:  21414537 ]

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