Document Detail

Pro- and Anti-inflammatory Cytokines in Gingival Crevicular Fluid and Serum of Rheumatoid Arthritis and Chronic Periodontitis Patients.
MedLine Citation:
PMID:  22414257     Owner:  NLM     Status:  Publisher    
Background: To evaluate pro- and anti-inflammatory cytokine levels in gingival crevicular fluid (GCF) and serum of rheumatoid arthritis (RA) and chronic periodontitis (CP) patients in order to assess whether cytokine profiles are distinguishing RA and CP patients while using healthy patients as background controls. Methods: A total of 49 patients, 17 RA patients [3 males and 14 females; mean age, 47.82±10.74], 16 CP patients [10 males and 6 females; mean age, 44.00±7.00], and 16 controls [8 males and 8 females; mean age 28.06±6.18]. RA patients were under the supervision of rheumatologists and 15 of the RA patients were being treated with methotrexate-sulfasalazine combined therapy and 2 of the patients were being treated with leflunomid therapy. Periodontal parameters (plaque index, gingival index, probing depth, clinical attachment level) were recorded. Interleukin (IL)-1β, IL-4, IL-10 and tumor necrosis factor (TNF)-α were determined in GCF and IL-1β and IL-10 in serum by ELISA. Results: There was significant difference found between RA, CP and controls for all periodontal parameters (p<0.05). The total amount and concentration of GCF IL-1 β, IL-4, IL-10 and TNF-α were similar in RA and CP (p>0.05). While the total amount and concentration of serum IL-10 was not significantly different between the groups (p>0.05),serum IL-1β was significantly lower in the RA group compared to CP and controls and were higher in GCF of the RA group compared to the CP group. Conclusions: Although clinical periodontal disease parameters indicated more severe periodontal disease in CP compare to RA, immunologic evaluation did not reveal consistent results regarding pro- and anti-inflammatory cytokine levels. This might be a result of the use of NSAIDs and rheumatoid agents by RA patients.
Burcu Cetinkaya; Esra Guzeldemir; Ersin Ogus; Sule Bulut
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-13
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey.
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