Document Detail


Prior pregastric food stimulation and gastrin-releasing peptide1-27 (GRP) synergize to inhibit sham feeding.
MedLine Citation:
PMID:  10477128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis that prior pregastric food stimulation is sufficient to reveal an inhibitory effect of gastrin-releasing peptide1-27 (GRP) on sham feeding was tested in 11 male rats equipped with chronic gastric cannulas. Rats were sham fed a high-carbohydrate solution during a 45-min test session, after 17-h food deprivation. GRP (16 or 32 microg/kg) or saline was injected intraperitoneally either at the onset or 5 or 15 min after the onset of sham feeding. This allowed for a 0-, 5-, or 15-min period of pregastric food stimulation before GRP or saline injections. Sham intake was recorded every 5 min, and behavior was observed every minute. GRP inhibited sham feeding when it was administered after 5 or 15 min of prior pregastric food stimulation, but not when it was administered at test onset. A nonsignificant increase in resting behavior and decrease in feeding behavior were associated with the decrease in sham feeding. No anomalous behaviors were noted. We conclude that a synergy between GRP and prior pregastric, presumably oral, food stimulation is sufficient to inhibit sham feeding.
Authors:
L Asarian; N Geary
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  20     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-16     Completed Date:  1999-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  731-6     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University, New York Presbyterian Hospital, Westchester Division, White Plains 10605, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Feeding Behavior / drug effects*
Food*
Gastrin-Releasing Peptide / pharmacology*
Male
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
MH 51135/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
80043-53-4/Gastrin-Releasing Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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