| Prior intense exercise reduces arterial carbon dioxide pressure in extreme obesity. | |
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MedLine Citation:
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PMID: 20926039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Unlike normal weight individuals, individuals with extreme obesity do not show a decrease in arterial carbon dioxide pressure (PaCO₂) from rest to peak exercise. This indicates that breathing is compromised. The objective of this study was to determine if prior high intensity exercise lowers PaCO₂ in comparison with a first bout, normalized for the same metabolic rate. METHODS: Oxygen consumption during incremental, ramped exercise was matched to constant workload exercise (75% of peak power). Both protocols were to volitional exhaustion 39 ± 8 min apart. Eleven obese subjects (BMI = 47 ± 8 kg/m², aerobic capacity = 2.3 ± 0.6 L/min) were evaluated. Forty paired samples were obtained at the same metabolic rate between the two protocols. RESULTS: The mean absolute difference and 95% CI were large for arterial oxygen pressure (PaO₂) = 9 (6, 11) mmHg and alveolar to arterial oxygen pressure difference (AaDO2) = 7 (5, 8) mmHg. The mean absolute difference for arterial oxyhemoglobin saturation (%SaO₂) = 0.5 (0.4, 0.7) %; PaCO2 = 4 (3, 4) mmHg; physiological dead space to tidal volume ratio (VD/VT) = 0.04 (0.03, 0.05); and alveolar ventilation (VA) = 3 (2, 4) L/min. The recovery period after the first bout of exercise reduced the PaCO₂ by 3 mmHg when matched for similar metabolic rates. Constant workload exercise predicted VA, %SaO2, V(D)/V(T), and PaCO₂, but not PaO₂ or AaDO₂ during incremental exercise at similar metabolic rates. CONCLUSION: Given a sufficient chemical stimulus, obese subjects will attempt to breathe more, although this does not mean more VA, which removes CO₂. |
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Authors:
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Gerald S Zavorsky; Do Jun Kim; Lauren M Cass; Franco Carli |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-01 |
Journal Detail:
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Title: Clinical and investigative medicine. Médecine clinique et experimentale Volume: 33 ISSN: 1488-2353 ISO Abbreviation: Clin Invest Med Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-07 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804071 Medline TA: Clin Invest Med Country: Canada |
Other Details:
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Languages: eng Pagination: E321-34 Citation Subset: IM |
Affiliation:
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Marywood University, Scranton, PA 18509, USA. zavorsky@marywood.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology Carbon Dioxide / blood* Exercise / physiology* Female Humans Male Obesity / blood*, physiopathology* Partial Pressure |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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