Document Detail


Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.
MedLine Citation:
PMID:  15150725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Results of this study support the free-radical theory of aging and demonstrated that providing higher levels of vitamin E in food resulted in higher serum vitamin E concentrations and improved performance on landmark-discrimination tasks in aged dogs. Factors other than vitamin E also contributed to the response but remain undefined.
Authors:
Candace J Ikeda-Douglas; Steven C Zicker; Jimena Estrada; Dennis E Jewell; Norton W Milgram
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary therapeutics : research in applied veterinary medicine     Volume:  5     ISSN:  1528-3593     ISO Abbreviation:  Vet. Ther.     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-19     Completed Date:  2004-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100936368     Medline TA:  Vet Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-16     Citation Subset:  IM    
Affiliation:
Department of Life Sciences, University of Toronto at Scarborough, Toronto, Ontario, M1C 1A4, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Antioxidants / administration & dosage,  pharmacology*
Carnitine / administration & dosage,  pharmacology
Diet*
Discrimination Learning / drug effects*,  physiology*
Distance Perception
Dogs / physiology
Thioctic Acid / administration & dosage,  pharmacology
Vitamin E / administration & dosage,  blood,  pharmacology
Chemical
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 541-15-1/Carnitine; 62-46-4/Thioctic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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