| Prior Endurance Exercise Prevents Postprandial Lipemia-Induced Increases in Reactive Oxygen Species in Circulating CD31+ Cells. | |
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MedLine Citation:
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PMID: 21930598 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We hypothesized that prior exercise would prevent postprandial lipemia (PPL)-induced increases in intracellular reactive oxygen species (ROS) in three distinct circulating angiogenic cell (CAC) subpopulations. CD34+, CD31+/CD14-/CD34-, and CD31+/CD14+/CD34- CACs were isolated from blood samples obtained from ten healthy men before and 4 hr after ingesting a high fat meal with or without ~50 min of prior endurance exercise. Significant PPL-induced increases in ROS production in both sets of CD31+ cells were abolished by prior exercise. Experimental ex vivo inhibition of NADPH oxidase activity and mitochondrial ROS production indicated that mitochondria were the primary source of PPL-induced oxidative stress. The attenuated increases in ROS with prior exercise were associated with increased antioxidant gene expression in CD31+/CD14-/CD34- cells and reduced intracellular lipid uptake in CD31+/CD14+/CD34- cells. These findings were associated with systemic cardiovascular benefits of exercise, as serum TG, OxLDL, and plasma EMP concentrations were lower in the prior exercise trial than the control trial. In conclusion, prior exercise completely prevents PPL-induced increases in ROS in CD31+/CD14-/CD34- and CD31+/CD14+/CD34- cells. The mechanisms underlying the effects of exercise on CAC function appear to vary among specific CAC types. |
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Authors:
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Nathan T Jenkins; Rian Q Landers; Sunny R Thakkar; Xiaoxuan Fan; Michael D Brown; Steven J Prior; Espen E Spangenburg; James M Hagberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-19 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Maryland College Park; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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