| Prions, protein homeostasis, and phenotypic diversity. | |
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MedLine Citation:
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PMID: 20071174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prions are fascinating but often misunderstood protein aggregation phenomena. The traditional association of the mammalian prion protein with disease has overshadowed a potentially more interesting attribute of prions: their ability to create protein-based molecular memories. In fungi, prions alter the relationship between genotype and phenotype in a heritable way that diversifies clonal populations. Recent findings in yeast indicate that prions might be much more common than previously realized. Moreover, prion-driven phenotypic diversity increases under stress, and can be amplified by the dynamic maturation of prion-initiating states. In this article, we suggest that these qualities allow prions to act as 'bet-hedging' devices that facilitate the adaptation of yeasts to stressful environments, and might speed the evolution of new traits. |
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Authors:
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Randal Halfmann; Simon Alberti; Susan Lindquist |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-01-12 |
Journal Detail:
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Title: Trends in cell biology Volume: 20 ISSN: 1879-3088 ISO Abbreviation: Trends Cell Biol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-06-03 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 125-33 Citation Subset: IM |
Affiliation:
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Whitehead Institute for Biomedical Research, Cambridge, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Epigenesis, Genetic
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physiology Gene Expression Regulation, Fungal Glutathione Peroxidase / physiology Homeostasis / genetics Phenotype* Prions / genetics*, physiology Protein Conformation Saccharomyces cerevisiae / genetics*, metabolism Saccharomyces cerevisiae Proteins / genetics, metabolism, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM025874-30/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Prions; 0/Saccharomyces cerevisiae Proteins; EC 1.11.1.9/Glutathione Peroxidase; EC 1.11.1.9/URE2 protein, S cerevisiae |
| Comments/Corrections | |
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