| Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in zitter rats. | |
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MedLine Citation:
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PMID: 7909925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to elucidate the relationship between the prion protein (PrP) structure and the development of spongiform encephalopathy in zitter rats, we analyzed the nucleotide sequences and restriction fragment length variation (RFLV) of the Prn gene encoding PrP in zitter rats and inbred SD/J rats as a control. Prn genes from two strains had identical nucleotide sequences in their coding sequences. Obvious RFLV on the locus was not detected in zitter rats by a Southern blot hybridization. Consistently, zitter rat brains express the normal cellular PrP (PrPC), but do not accumulate the protease-resistant modified isoform (PrPSC). These results indicate that PrP is not involved in the pathogenesis of spongiform encephalopathy in zitter rats. |
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Authors:
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H Gomi; T Ikeda; T Kunieda; S Itohara; S B Prusiner; K Yamanouchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 166 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-06-09 Completed Date: 1994-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 171-4 Citation Subset: IM |
Affiliation:
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Institute for Virus Research, Kyoto University, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/S69654 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Blotting, Southern Blotting, Western Brain / pathology Molecular Sequence Data Open Reading Frames Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Prion Diseases / genetics, metabolism* Prions / metabolism* Rats Rats, Mutant Strains Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Prions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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