Document Detail

Prion-like polymerization as a signaling mechanism.
MedLine Citation:
PMID:  25457352     Owner:  NLM     Status:  Publisher    
The innate immune system uses pattern recognition receptors such as RIG-I and NLRP3 to sense pathogen invasion and other danger signals. Activation of these receptors induces robust signal transduction cascades that trigger the production of cytokines important for host protection. MAVS and ASC are essential adaptor proteins downstream of RIG-I and NLRP3, respectively, and both contain N-terminal domains belonging to the death domain superfamily. Recent studies suggest that both MAVS and ASC form functional prion-like fibers through their respective death domains to propagate downstream signaling. Here, we review these findings, and in this context discuss the emerging concept of prion-like polymerization in signal transduction. We further examine the potential benefits of this signaling strategy, including signal amplification, host evolutionary advantage, and molecular memory.
Xin Cai; Zhijian J Chen
Publication Detail:
Type:  REVIEW     Date:  2014-11-12
Journal Detail:
Title:  Trends in immunology     Volume:  35     ISSN:  1471-4981     ISO Abbreviation:  Trends Immunol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  100966032     Medline TA:  Trends Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  622-630     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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