Document Detail

Prion genotypes in Central America suggest selection for the V129 allele.
MedLine Citation:
PMID:  16287045     Owner:  NLM     Status:  MEDLINE    
Using the well-characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru-like diseases, which has influenced its allele frequency.
John Hardy; Sonja Scholz; Whitney Evans; Lev Goldfarb; Andrew Singleton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics     Volume:  141B     ISSN:  1552-4841     ISO Abbreviation:  Am. J. Med. Genet. B Neuropsychiatr. Genet.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-03     Completed Date:  2006-03-28     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  101235742     Medline TA:  Am J Med Genet B Neuropsychiatr Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-5     Citation Subset:  IM    
Copyright Information:
(c) 2005 Wiley-Liss, Inc.
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MeSH Terms
Central America
Gene Frequency
Genetic Variation
Prions / genetics*
Selection, Genetic*
South America
Valine / genetics*
Grant Support
G0701075//Medical Research Council
Reg. No./Substance:
0/Prions; HG18B9YRS7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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