Document Detail


Prion genotypes in Central America suggest selection for the V129 allele.
MedLine Citation:
PMID:  16287045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using the well-characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru-like diseases, which has influenced its allele frequency.
Authors:
John Hardy; Sonja Scholz; Whitney Evans; Lev Goldfarb; Andrew Singleton
Related Documents :
21073885 - The α7 nicotinic acetylcholine receptor and the acute stress response: maternal genotyp...
21225715 - Genome-wide association study of rheumatoid arthritis in korea: population-specific loc...
23643555 - Emergence of a novel lineage genetically divergent from the predominant ind2001 lineage...
21553015 - β-tubulin genotypes in six species of cyathostomins from anthelmintic-naive przewalski ...
7729825 - Apolipoprotein e polymorphism and susceptibility to alzheimer's disease.
8882145 - Genetics of osteoarthritis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics     Volume:  141B     ISSN:  1552-4841     ISO Abbreviation:  Am. J. Med. Genet. B Neuropsychiatr. Genet.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-03     Completed Date:  2006-03-28     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  101235742     Medline TA:  Am J Med Genet B Neuropsychiatr Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-5     Citation Subset:  IM    
Copyright Information:
(c) 2005 Wiley-Liss, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alleles
Central America
Gene Frequency
Genetic Variation
Genotype
Humans
Prions / genetics*
Selection, Genetic*
South America
Valine / genetics*
Grant Support
ID/Acronym/Agency:
G0701075//Medical Research Council
Chemical
Reg. No./Substance:
0/Prions; HG18B9YRS7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic etiology of stability of attention problems in young adulthood.
Next Document:  Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia.