| Prion and anti-codon usage: does infectious PrP alter tRNA abundance to induce misfolding of PrP? | |
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MedLine Citation:
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PMID: 18809261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The "protein-only" hypothesis of prion diseases views the infectious agent as devoid of nucleic acids and consisting of misfolded prion proteins (PrP(Sc)) which, upon infiltration into host cells, act as a template that induces transformation of wild-type protein (PrP(C)) to the pathological form by unknown mechanisms. The two isoforms are identical in amino-acid composition. By analogy to reported "silent" mutations in which utilization of relatively rare tRNAs alter protein folding pattern, we postulate that misfolded PrP(Sc) alters tRNAs abundance in prion-infected cells and results in different rates of co-translational folding of PrP, leading to the formation of additional misfolded PrP(Sc). We analyze experiments that might link tRNAs to prions. This concept of "PrP-seed and tRNA-soil" envisages a vicious cycle in which PrP(Sc) levels govern specific tRNA usage, whose alteration subsequently transforms resident PrP(C) to PrP(Sc), causing the cycle to repeat itself ad infinitum. |
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Authors:
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Oded Rechavi; Yoel Kloog |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-21 |
Journal Detail:
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Title: Medical hypotheses Volume: 72 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2008-12-29 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 193-5 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel-Aviv, Israel. odedrechavi@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Codon
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genetics* Humans Prions / genetics* Protein Folding* RNA, Transfer / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/Prions; 9014-25-9/RNA, Transfer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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