Document Detail


Principles and results of high-intensity focused ultrasound for localized prostate cancer.
MedLine Citation:
PMID:  15452554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Focused ultrasound holds promise in a large number of therapeutic applications. It has long been known that high-intensity focused ultrasound (HIFU) can kill tissue through coagulative necrosis. However, it is only in recent years that practical clinical applications are becoming possible, with the development of high-power ultrasound arrays and noninvasive monitoring methods. In the last decade, HIFU have been adapted and used to treat localized prostate cancer and it is now commercially available in Europe. In this article, preclinical studies and clinical development of prostate HIFU as well as early clinical results from our center and international studies are reviewed. Early results demonstrated that prostate HIFU is efficient to obtain local control for low- and intermediate-risk localized prostate cancer; however, long-term follow-up is still needed to estimate the efficacy of prostate HIFU in terms of specific cancer mortality. This makes HIFU a viable alternative in patients not candidate for radical therapy.
Authors:
M Colombel; A Gelet
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostate cancer and prostatic diseases     Volume:  7     ISSN:  1365-7852     ISO Abbreviation:  Prostate Cancer Prostatic Dis.     Publication Date:  2004  
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9815755     Medline TA:  Prostate Cancer Prostatic Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Affiliation:
Urology and Transplantation Surgery, Edouard Herriot Medical Center, Claude-Bernard University, 5 Place d'Arsonval, 69437, Lyon Cedex, France. marc.colombel@chi-lyon.fr
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MeSH Terms
Descriptor/Qualifier:
Humans
Male
Prostatic Neoplasms / pathology,  therapy*
Ultrasound, High-Intensity Focused, Transrectal* / instrumentation,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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