Document Detail

Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.
MedLine Citation:
PMID:  23530999     Owner:  NLM     Status:  MEDLINE    
Renshaw cells provide a convenient model to study spinal circuit development during the emergence of motor behaviors with the goal of capturing principles of interneuron specification and circuit construction. This work is facilitated by a long history of research that generated essential knowledge about the characteristics that define Renshaw cells and the recurrent inhibitory circuit they form with motoneurons. In this review, we summarize recent data on the specification of Renshaw cells and their connections. A major insight from these studies is that the basic Renshaw cell phenotype is specified before circuit assembly, a result of their early neurogenesis and migration. Connectivity is later added, constrained by their placement in the spinal cord. Finally, different rates of synapse proliferation alter the relative weights of different inputs on postnatal Renshaw cells. Based on this work some general principles on the integration of spinal interneurons in developing motor circuits are derived.
Francisco J Alvarez; Ana Benito-Gonzalez; Valerie C Siembab
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1279     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-05-17     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-31     Citation Subset:  IM    
Copyright Information:
© 2013 New York Academy of Sciences.
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MeSH Terms
Cell Differentiation* / physiology
Concept Formation
Interneurons / physiology*
Models, Biological
Motor Neurons / cytology,  physiology*
Neural Inhibition / physiology*
Neurogenesis / physiology
Spinal Cord / cytology*,  growth & development,  physiology
Synapses / physiology
Grant Support

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