Document Detail

Principal transcriptional regulation and genome-wide system interactions of the Asp-family and aromatic amino acid networks of amino acid metabolism in plants.
MedLine Citation:
PMID:  20364431     Owner:  NLM     Status:  MEDLINE    
Amino acid metabolism is among the most important and best recognized networks within biological systems. In plants, amino acids serve multiple functions associated with growth. Besides their function in protein synthesis, the amino acids are also catabolized into energy-associated metabolites as well we into numerous secondary metabolites, which are essential for plant growth and response to various stresses. Despite the central importance of amino acids in plants growth, elucidation of the regulation of amino acid metabolism within the context of the entire system, particularly transcriptional regulation, is still in its infancy. The different amino acids are synthesized by a number of distinct metabolic networks, which are expected to possess regulatory cross interactions between them for proper coordination of their interactive functions, such as incorporation into proteins. Yet, individual amino acid metabolic networks are also expected to differentially cross interact with various genome-wide gene expression programs and metabolic networks, in respect to their functions as precursors for various metabolites with distinct functions. In the present review, we discuss our recent genomics, metabolic and bioinformatics studies, which were aimed at addressing these questions, focusing mainly on the Asp-family metabolic network as the main example and also comparing it to the aromatic amino acids metabolic network as a second example (Angelovici et al. in Plant Physiol 151:2058-2072, 2009; Less and Galili in BMC Syst Biol 3:14, 2009; Tzin et al. in Plant J 60:156-167, 2009). Our focus on these two networks is because of the followings: (i) both networks are central to plant metabolism and growth and are also precursors for a wide range of primary and secondary metabolites that are indispensable to plant growth; (ii) the amino acids produced by these two networks are also essential to the nutrition and health of human and farm animals; and (iii) both networks contain branched pathways requiring extensive regulation of fluxes between the different branches. Additional views on the biochemistry, regulation and functional significance of the Asp-family and aromatic amino acid networks and some of their associated metabolites that are discussed in the present report, as well as the nutritional importance of Lys and Trp to human and farm animals, and attempts to improve Lys level in crop plants, can be obtained from the following reviews as examples (Radwanski and Last in Plant Cell 7:921-934, 1995; Halkier and Gershenzon in Annu Rev Plant Biol 57:303-333, 2006; Ufaz and Galili in Plant Physiol 147:954-961, 2008; Jander and Joshi in Mol Plant 3:54-65, 2010).
Hadar Less; Ruthie Angelovici; Vered Tzin; Gad Galili
Publication Detail:
Type:  Journal Article     Date:  2010-04-04
Journal Detail:
Title:  Amino acids     Volume:  39     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1023-8     Citation Subset:  IM    
Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel.
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MeSH Terms
Amino Acids / biosynthesis,  metabolism
Amino Acids, Aromatic / biosynthesis*,  metabolism
Arabidopsis / enzymology,  genetics,  metabolism
Aspartic Acid / biosynthesis*,  metabolism
Computational Biology
Gene Expression Regulation, Plant
Gene Regulatory Networks
Lysine / biosynthesis*,  metabolism
Metabolic Networks and Pathways
Plants / genetics,  growth & development,  metabolism*
Plants, Genetically Modified / enzymology,  metabolism
Seeds / enzymology
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Aromatic; 56-84-8/Aspartic Acid; 56-87-1/Lysine

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