Document Detail


Principal transcriptional programs regulating plant amino acid metabolism in response to abiotic stresses.
MedLine Citation:
PMID:  18375600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using a bioinformatics analysis of public Arabidopsis (Arabidopsis thaliana) microarray data, we propose here a novel regulatory program, combining transcriptional and posttranslational controls, which participate in modulating fluxes of amino acid metabolism in response to abiotic stresses. The program includes the following two components: (1) the terminal enzyme of the module, responsible for the first catabolic step of the amino acid, whose level is stimulated or repressed in response to stress cues, just-in-time when the cues arrive, principally via transcriptional regulation of its gene; and (2) the initiator enzyme of the module, whose activity is principally modulated via posttranslational allosteric feedback inhibition in response to changes in the level of the amino acid, just-in-case when it occurs in response to alteration in its catabolism or sequestration into different intracellular compartments. Our proposed regulatory program is based on bioinformatics dissection of the response of all biosynthetic and catabolic genes of seven different pathways, involved in the metabolism of 11 amino acids, to eight different abiotic stresses, as judged from modulations of their mRNA levels. Our results imply that the transcription of the catabolic genes is principally more sensitive than that of the biosynthetic genes to fluctuations in stress-associated signals. Notably, the only exception to this program is the metabolic pathway of Pro, an amino acid that distinctively accumulates to significantly high levels under abiotic stresses. Examples of the biological significance of our proposed regulatory program are discussed.
Authors:
Hadar Less; Gad Galili
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-03-28
Journal Detail:
Title:  Plant physiology     Volume:  147     ISSN:  0032-0889     ISO Abbreviation:  Plant Physiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-09-03     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0401224     Medline TA:  Plant Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  316-30     Citation Subset:  IM    
Affiliation:
Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Arabidopsis / enzymology,  genetics,  physiology*
Biosynthetic Pathways / genetics,  physiology
Computational Biology
Plant Proteins / metabolism
Salinity
Time Factors
Water / physiology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Plant Proteins; 7732-18-5/Water
Comments/Corrections

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