Document Detail

Primordia vita. Deconvolution from modern sequences.
MedLine Citation:
PMID:  17120122     Owner:  NLM     Status:  MEDLINE    
Evolution of the triplet code is reconstructed on the basis of consensus temporal order of appearance of amino acids. Several important predictions are confirmed by computational sequence analyses. The earliest amino acids, alanine and glycine, have been encoded by GCC and GGC codons, as today. They were succeeded, respectively, by A- and G-series of amino acids, encoded by pyrimidine-central and purine-central codons. The length of the earliest proteins is estimated to be 6-7 residues. The earliest mRNAs were short G+C-rich molecules. These short sequences could have formed hairpins. This is confirmed by analysis of modern prokaryotic mRNA sequences. Predominant size of detected ancient hairpins also corresponds to 6-7 amino acids, as above. Vestiges of last common ancestor can be found in extant proteins in form of entirely conserved short sequences of size six to nine residues present in all or almost all sequenced prokaryotic proteomes (omnipresent motifs). The functions of the topmost conserved octamers are not involved in the basic elementary syntheses. This suggests an initial abiotic supply of amino acids, bases and sugars.
Edward N Trifonov; Idan Gabdank; Danny Barash; Yehoshua Sobolevsky
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  36     ISSN:  0169-6149     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-19     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  559-65     Citation Subset:  IM; S    
Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel.
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MeSH Terms
Base Sequence
Evolution, Molecular*
GC Rich Sequence / genetics
Genetic Code / genetics*
Peptides / genetics
Proteins / genetics
RNA, Messenger / genetics
Reg. No./Substance:
0/Peptides; 0/Proteins; 0/RNA, Messenger

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