| Primitive (developmental) reflexes and diffuse cerebral dysfunction in schizophrenia and bipolar affective disorder: overrepresentation in patients with tardive dyskinesia. | |
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MedLine Citation:
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PMID: 2896519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primitive (developmental) reflexes are present in fetal and infant life, but disappear in adulthood. Their elicitation in later life usually occurs in association with cortical or diffuse cerebral dysfunction and suggests a new approach to the issue of whether tardive dyskinesia is particularly likely to occur in patients with organic brain disorder(s). Sixty-six patients with schizophrenia (age range 50-86) and 18 with bipolar affective disorder (age range 40-77) were assessed for the presence of involuntary movements and for the release of the grasp, palmomental, snout, corneomandibular, and glabellar reflexes. In each diagnostic group, patients with involuntary movements showed a significant excess of primitive reflexes in comparison with otherwise indistinguishable patients without such movements. These results complement recent reports that similar patients with involuntary movements also show greater cognitive impairment and point anew to an association between the presence of tardive dyskinesia and of organic brain dysfunction. They raise again the issue of whether or not such dysfunction may be a consequence of neurodevelopmental abnormality rather than of neurodegenerative processes. |
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Authors:
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H A Youssef; J L Waddington |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological psychiatry Volume: 23 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-06-13 Completed Date: 1988-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 791-6 Citation Subset: IM |
Affiliation:
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St. Davnet's Hospital, Monaghan, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antipsychotic Agents / adverse effects Bipolar Disorder / physiopathology* Brain / physiopathology Brain Damage, Chronic / physiopathology* Delirium, Dementia, Amnestic, Cognitive Disorders / physiopathology* Dyskinesia, Drug-Induced / physiopathology* Female Humans Male Middle Aged Reflex, Abnormal / physiopathology* Risk Factors Schizophrenia / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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