| Priming of neutrophils after elective percutaneous transluminal coronary angioplasty is unrelated to accompanying brief myocardial ischemia. | |
| | |
MedLine Citation:
|
PMID: 9363739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to investigate the effect of brief myocardial ischemia and vascular trauma induced by elective percutaneous transluminal coronary angioplasty on in vivo 'priming' and activation of neutrophils. PATIENTS AND METHODS: We studied 16 patients undergoing elective coronary angioplasty for symptomatic coronary artery disease and a control group of seven patients undergoing diagnostic cardiac catheterization. Free radical production from purified neutrophils (Ficoll-Hypaque density gradient method) was measured indirectly by the chemiluminescence method. Myocardial ischemia during balloon inflation was assessed by serial lactate determinations from coronary sinus and arterial blood. The degree of transient angioplasty-related myocardial ischemia was related to the oxidative response of activated neutrophils. RESULTS: Mean (+/-S.E.M.) oxidative response, i.e. the lucigenin- and luminol-enhanced-chemiluminescence (counts per minute) of neutrophils sampled from the coronary sinus increased significantly after percutaneous transluminal coronary angioplasty (Lucigenin-chemiluminescence: pre-angioplasty 3.69+/-0.64x10(5) vs. post-angioplasty 7.08+/-1.2x10(5), P<0.01; Luminol-chemiluminescence: pre-angioplasty 2.81+/-0.67x10(6) vs. post-angioplasty 5.2+/-0.92x10(6), P<0.01). Twelve of 16 patients developed transient cardiac lactate production (mean coronary sinus lactate excess: +0.12 mmol/l) and three disclosed a lactate extraction ratio <10%, both suggestive of myocardial ischemia. However, there was no correlation between the cardiac lactate production and the increased oxidative response after coronary angioplasty (r2 (Lucigenin-chemiluminescence)=0.02, n.s.; r2 (Luminol-chemiluminescence)=0.06, n.s.). CONCLUSION: 'Priming' of neutrophils, as reflected by increased oxidative response, is likely to occur after coronary angioplasty, but not after the angiographic procedure itself. However, 'priming' seems to be unrelated to the transient brief period of myocardial ischemia and rather depends on an alternative mechanism. |
| | |
Authors:
|
E Giannitsis; I Tettenborn; G Schmücker; R Mitusch; U Wiegand; J Potratz; A Sheikhzadeh; U Stierle |
Related Documents
:
|
10406069 - Primary angioplasty for acute myocardial infarction: the zwolle approach. 3155619 - Predictive value of early maximal exercise test and thallium scintigraphy after success... 1616379 - Emergency coronary artery bypass surgery for failed percutaneous coronary angioplasty. ... 15550729 - Primary angioplasty of unprotected left main coronary artery for acute anterolateral my... 9438169 - A late retroperitoneal hematoma mimicking acute appendicitis--an unusual complication o... 1571979 - Percutaneous transluminal coronary angioplasty of coronary artery embolism. 7835359 - The use of gianturco-roubin flexible metallic coronary stents in old saphenous vein gra... 6827869 - Clinical algorithms for prehospital cardiac care. 15061869 - A single-nucleotide polymorphism in the human p27kip1 gene (-838c>a) affects basal prom... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of cardiology Volume: 61 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1997 Oct |
Date Detail:
|
Created Date: 1997-12-09 Completed Date: 1997-12-09 Revised Date: 2006-07-12 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 229-37 Citation Subset: IM |
Affiliation:
|
University of Luebeck, Department of Cardiology, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Chemiluminescent Measurements Coronary Disease / therapy Humans Middle Aged Myocardial Ischemia / physiopathology* Neutrophils / physiology* Oxidation-Reduction Regression Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of age on cardiovascular risk factors in Chinese women.
Next Document: Effect of ST segment measurement point on performance of exercise ECG analysis.