Document Detail

Primer: strengths and weaknesses of meta-analysis.
MedLine Citation:
PMID:  18227829     Owner:  NLM     Status:  MEDLINE    
Properly conducted meta-analyses that are based on systematic reviews of the literature allow the conclusive synthesis of accumulating scientific evidence. Systematic reviews, with or without meta-analyses, offer a more objective appraisal of the available evidence compared with traditional narrative reviews. Combining data from independent studies using meta-analytic methods can improve statistical precision, but cannot prevent bias as such. The validity of meta-analyses depends on the methodological quality of the included studies, the eligibility criteria used for the meta-analysis, and the various reporting biases. In this Review we examine the analytical strengths of, and the main problems encountered by, both systematic reviews and meta-analyses, focusing on how to best assess the validity of each for the practicing clinician.
Axel Finckh; Martin R Tramèr
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Rheumatology     Volume:  4     ISSN:  1745-8390     ISO Abbreviation:  -     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101261802     Medline TA:  Nat Clin Pract Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-52     Citation Subset:  IM    
Division of Rheumatology at University Hospitals of Geneva, Geneva, Switzerland.
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MeSH Terms
Clinical Trials as Topic
Evidence-Based Medicine*
Meta-Analysis as Topic*
Publication Bias*
Quality Control
Review Literature as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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