Document Detail


Primed B cells present type-II collagen to T cells.
MedLine Citation:
PMID:  11967120     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of type-II collagen (CII)-induced arthritis (CIA) is dependent on a T-cell mediated activation of autoreactive B cells. However, it is still unclear if B cells can present CII to T cells. To investigate the role of B cells as antigen-presenting cells (APCs) for CII, we purified B cells from lymph nodes of immunized and nonimmunized mice. These B cells were used as APC for antigen-specific T-cell hybridomas. B cells from naïve mice did present native, triple-helical, CII (nCII) but also ovalbumin (OVA) and denatured CII (dCII) to antigen-specific T-cell hybridomas. In addition, B cells primed with nCII or OVA, but not dCII, activated the antigen-specific T-cell hybridomas two to three times better than naïve B cells. We conclude that antigen-primed B cells have the capacity to process and present CII to primed T cells, and antigen-primed antigen-specific B cells are more efficient as APC than naïve B cells. We further conclude that B cells have the potential to play an important role as APC in the development of CIA.
Authors:
M Holmdahl; M Vestberg; R Holmdahl
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  55     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-22     Completed Date:  2002-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  382-9     Citation Subset:  IM    
Affiliation:
Section for Medical Inflammation Research, Lund University, Lund, Sweden. meirav.holmdahl@inflam.lu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / immunology
Antigen-Presenting Cells / physiology*
Arthritis / etiology*
B-Lymphocytes / physiology*
Collagen Type II / immunology*
Macrophages / physiology
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Collagen Type II

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