Document Detail


Primate parturition and the role of the maternal circadian system.
MedLine Citation:
PMID:  7958165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several 24-h rhythms have been observed in the mother and in the fetus during primate gestation. In the mother, 24-h rhythms occur in biophysical variables, pregnancy-associated plasma hormones and preparturient myometrial activity. In addition, both pregnant non-human primates and pregnant women deliver preferentially during the night and early morning hours. A crucial question pertaining circadian rhythms is whether 24-h rhythms that may be observed during pregnancy are endogenous in nature and entrained by the light-dark cycle or whether the daily photoperiod is a causal stimulus. Our work has addressed the role of the maternal and fetal circadian system for 24-h rhythms in pregnancy-associated maternal plasma hormones, preparturient myometrial activity and parturition in human and non-human primate pregnancy. In the present review, the results of some of our studies are being discussed in combination with data available from the literature. It is apparent that 24-h rhythms that may be observed during primate pregnancy are determined by the maternal circadian system, suggesting that the developing fetus receives information about the ambient time of the day via the mother. Fetal entrainment by the mother may ensure fetal cooperation so that parturition occurs at the most favorable time of the day. We conclude that the functioning of the maternal circadian system is integral to the pregnant state. Thus, proper care and management of pregnant women and the ultimate outcome of obstetrics may benefit from more timely methodologies. A chronopharmacological attitude towards the prevention of premature labor and the induction and augmentation of labor at term may yield new therapeutic strategies. Such an approach will enable delivery to take place under optimal conditions for mother and child.
Authors:
M B Honnebier; P W Nathanielsz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  55     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-08     Completed Date:  1994-12-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  193-203     Citation Subset:  IM    
Affiliation:
Department of Physiology, Cornell University, Ithaca, NY 14853-6401.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm*
Female
Fetus / physiology
Labor, Obstetric / physiology*
Pregnancy
Pregnancy, Animal / physiology*
Primates / physiology*
Species Specificity
Grant Support
ID/Acronym/Agency:
NICHD HD 21350/HD/NICHD NIH HHS; NICHD HD 26203/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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