| Primate model for long-term study of intraventricularly or intrathecally administered drugs and intracranial pressure. | |
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MedLine Citation:
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PMID: 402027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinal fluid without tissue damage, prod, enables spinoventricular perfusion, and permits ventricular cerebrospinal fluid sampling over extended periods in unanethetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man. |
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Authors:
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J H Wood; D G Poplack; W A Bleyer; A K Ommaya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 195 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-03-31 Completed Date: 1977-03-31 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-501 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopharmaceutics Catheterization / methods Cerebral Ventricles / physiology Haplorhini Injections, Intraventricular / methods* Injections, Spinal / methods* Intracranial Pressure* Macaca mulatta Methotrexate / cerebrospinal fluid Subarachnoid Space / physiology |
| Chemical | |
Reg. No./Substance:
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59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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