Document Detail


Primate model for long-term study of intraventricularly or intrathecally administered drugs and intracranial pressure.
MedLine Citation:
PMID:  402027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinal fluid without tissue damage, prod, enables spinoventricular perfusion, and permits ventricular cerebrospinal fluid sampling over extended periods in unanethetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man.
Authors:
J H Wood; D G Poplack; W A Bleyer; A K Ommaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  195     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-501     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biopharmaceutics
Catheterization / methods
Cerebral Ventricles / physiology
Haplorhini
Injections, Intraventricular / methods*
Injections, Spinal / methods*
Intracranial Pressure*
Macaca mulatta
Methotrexate / cerebrospinal fluid
Subarachnoid Space / physiology
Chemical
Reg. No./Substance:
59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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