| Primate kidney function in hemorrhagic shock as influenced by dibutyryl cyclic AMP. | |
| | |
MedLine Citation:
|
PMID: 178188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Standardized hemorrhagic shock was employed to study alterations in electrolyte and water handling in the owl monkey, either normally hydrated or moderately dehydrated. Increase in fractional clearance of osmolarity,sodium, and calcium occurred with retransfusion after the hypotensive phase. In the hydrated animals, free-water clearance became positive, and the urine-to-plasma osmolarity ratio [(U/P)osM] decreased below 1.0. In the dehydrated animals, free-water reabsorption (TCH2O) decreased but remained negative,while (U/P)osM remained above 1.0. Dibutyryl cyclic AMP (DBcAMP) was infused into the renal arterial supply in an attempt to correct a possible deficiency of cyclic AMP production. In the hydrated group, free-water clearance (CH2O) became more positive with infusion, and (U/P)osM decreased even further, with no effect on fractional sodium clearance. Effects were less or absent in the dehydrated group. Possible explanations for the observed effects of DBcAMP are considered. It was concluded that the loss of concentrating power seen in hemorrhagic shock occurs at a step beyond the production of cyclic AMP by adenylate cyclase. |
| | |
Authors:
|
E E Selkurt |
Related Documents
:
|
2309658 - The effect of sodium chloride concentration, water content, and protein on the gas chro... 15373958 - Fluid, electrolytes and nutrition: physiological and clinical aspects. 22721788 - Effects of surface chemical properties of activated carbon modified by amino-fluorinati... 22825808 - Air-breathing behavior and physiological responses to hypoxia and air exposure in the a... 15202708 - Different classes of proteases are involved in the response to drought of phaseolus vul... 20970808 - Hydrophobic/superhydrophobic oxidized metal surfaces showing negligible contact angle h... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 230 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1976 Mar |
Date Detail:
|
Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 724-30 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aotus trivirgatus Blood Pressure Bucladesine / administration & dosage, pharmacology* Calcium / urine Cyclic AMP / urine Dehydration / physiopathology Female Glomerular Filtration Rate Haplorhini Infusions, Parenteral Kidney / physiopathology* Kidney Concentrating Ability Male Shock, Hemorrhagic / physiopathology* Sodium / urine |
| Chemical | |
Reg. No./Substance:
|
362-74-3/Bucladesine; 60-92-4/Cyclic AMP; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The occurrence and frequency of type C virus-like particles in placentas from patients with systemic...
Next Document: Muscle fiber involvement during training of different intensities and durations.