Document Detail

Primate kidney function in hemorrhagic shock as influenced by dibutyryl cyclic AMP.
MedLine Citation:
PMID:  178188     Owner:  NLM     Status:  MEDLINE    
Standardized hemorrhagic shock was employed to study alterations in electrolyte and water handling in the owl monkey, either normally hydrated or moderately dehydrated. Increase in fractional clearance of osmolarity,sodium, and calcium occurred with retransfusion after the hypotensive phase. In the hydrated animals, free-water clearance became positive, and the urine-to-plasma osmolarity ratio [(U/P)osM] decreased below 1.0. In the dehydrated animals, free-water reabsorption (TCH2O) decreased but remained negative,while (U/P)osM remained above 1.0. Dibutyryl cyclic AMP (DBcAMP) was infused into the renal arterial supply in an attempt to correct a possible deficiency of cyclic AMP production. In the hydrated group, free-water clearance (CH2O) became more positive with infusion, and (U/P)osM decreased even further, with no effect on fractional sodium clearance. Effects were less or absent in the dehydrated group. Possible explanations for the observed effects of DBcAMP are considered. It was concluded that the loss of concentrating power seen in hemorrhagic shock occurs at a step beyond the production of cyclic AMP by adenylate cyclase.
E E Selkurt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  230     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  724-30     Citation Subset:  IM    
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MeSH Terms
Aotus trivirgatus
Blood Pressure
Bucladesine / administration & dosage,  pharmacology*
Calcium / urine
Cyclic AMP / urine
Dehydration / physiopathology
Glomerular Filtration Rate
Infusions, Parenteral
Kidney / physiopathology*
Kidney Concentrating Ability
Shock, Hemorrhagic / physiopathology*
Sodium / urine
Reg. No./Substance:
362-74-3/Bucladesine; 60-92-4/Cyclic AMP; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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