Document Detail


Primary writing tremor.
MedLine Citation:
PMID:  8595477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary writing tremor (PWT) is considered to be a type of task-specific tremor in which tremor predominantly occurs and interferes with handwriting. We describe the clinical and neurophysiological features of 21 patients (20 male and one female) with PWT. Mean age at tremor onset was 50.1 years. A family history of PWT was obtained from seven patients. Ten patients obtained benefit from drug treatment (mainly propranalol or primidone) and seven responded to alcohol. The writing speeds of the patients (mean +/- SEM: 73.1 +/- 6.6 letters per minute) when using their preferred hand were significantly reduced (Student's t test: P < 0.001) compared with those of healthy control subjects (mean +/- SEM: 127.7 +/- 6.4). Surface polymyography performed during writing showed 4.1-7.3 Hz rhythmic activity predominantly in the intrinsic hand and forearm muscles. Alternating, extensor activation alone, skipping from alternating to extensor activation, and co-contracting EMG patterns were recorded from the flexor and extensor muscles of the forearm. There was no evidence for excessive 'overflow' of this rhythmic EMG activity, as similar activity was detected in comparable muscle groups of healthy control subjects. Accelerometry confirmed that the frequency of PWT ranged from 4.1-7.3 Hz (median 5.5 Hz) and that normal subjects wrote with a 4.0-7.7 Hz oscillation (median 4.6 Hz). Forearm reciprocal inhibition was normal in PWT (n = 13), and thus patients with PWT can be distinguished from those with writer's cramp in whom decreased presynaptic inhibition has been found. Patients were sub-classified as having either type A (n = 11) or B (n = 10) PWT depending on whether tremor appeared during writing (type A: task induced tremor) or whilst writing and adopting the hand position used in writing (type B: positionally sensitive tremor). However, the only differences between these two groups were that a co-contracting EMG pattern and tremor induced by tendon taps to the volar aspect of the wrist were present in type B but not type A cases.
Authors:
P G Bain; L J Findley; T C Britton; J C Rothwell; M A Gresty; P D Thompson; C D Marsden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  118 ( Pt 6)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-04-16     Completed Date:  1996-04-16     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1461-72     Citation Subset:  AIM; IM    
Affiliation:
MRC Human Movement and Balance Unit, Institute of Neurology, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Disabled Persons
Ethanol / pharmacology
Female
H-Reflex
Handwriting*
Humans
Male
Median Nerve / physiopathology
Middle Aged
Myography
Neural Inhibition
Pedigree
Propranolol / therapeutic use
Reference Values
Tremor / drug therapy,  genetics,  physiopathology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
525-66-6/Propranolol; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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