Document Detail


Primary vascular anastomosis in growing pigs: comparison of polypropylene and polyglycolic acid sutures.
MedLine Citation:
PMID:  6262579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stenosis remains a significant problem in vascular anastomoses performed in the growing patient. This study compares the growth of vascular anastomoses performed with either polypropylene or polyglycolic acid sutures. End-to-end infrarenal aortic anastomoses were performed in 18 piglets. Twelve were performed with polypropylene; in six all sutures were placed in a continuous fashion (Group 1A), and in the other six the posterior sutures were continuous and the anterior were interrupted (Group B). Six anastomoses were performed with polyglycolic acid sutures placed in a continuous fashion (Group 2). The animals were killed 6 months following operation. The abdominal aorta was removed, measured, burst tested, and subjected to histologic studies. All anastomoses were patent. There were no burst failures at 300 mm Hg mean pressure. All polypropylene sutures in Group 1A and the continuous portion in Group 1B had straightened without breaking. Straightening without polypropylene suture breakage resulted in stricture in three Group 1A anastomoses and one Group 1B anastomosis; there was intraluminal polypropylene suture material in two Group 1A and five Group 1B anastomoses. Bowstring formation of the straightened, continuous portion of the polypropylene suture in two Group 1A anastomoses and one Group 1B anastomosis resulted in adherent thrombus. Group 2 anastomoses were without stricture and were grossly indistinguishable from adjacent normal vessel. Histologic examination showed varying degrees of chronic inflammation in the polypropylene anastomoses but negligible inflammation in the polyglycolic acid anastomoses. These results suggest that continuous suture techniques with polypropylene in growing vessels may result in stenosis and/or thrombosis. Moreover, synthetic absorbable polyglycolic acid sutures will be of use in vascular anastomoses in growing patients and in cases in which exacting technique with minimal postsurgical inflammation may be crucial to patency.
Authors:
W E Pae; J A Waldhausen; G A Prophet; W S Pierce
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  81     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / growth & development,  surgery*
Aortic Valve Stenosis / etiology
Models, Biological
Plastics* / adverse effects
Polyglycolic Acid* / adverse effects
Polypropylenes* / adverse effects
Sutures / standards*
Swine / growth & development*
Thrombosis / etiology
Grant Support
ID/Acronym/Agency:
F32HL05994/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Plastics; 0/Polypropylenes; 26009-03-0/Polyglycolic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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