| Primary treatment of macroprolactinomas with Parlodel LAR. | |
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MedLine Citation:
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PMID: 3414319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five patients, 3 women and 2 men, with macroprolactinomas characterized by extrasellar extension and basal plasma prolactin levels ranging from 4.6 to 102 U/l received six monthly injections of 50-100 mg Parlodel LAR, an injectable long-acting repeatable form of bromocriptine. The following observations were made: 1. Plasma prolactin levels fell dramatically in all patients and values in the normal range were obtained in 3 patients. 2. In all patients, the onset of tumour reduction was visible on CT scans made one week after the first Parlodel LAR injection. After six Parlodel LAR injections, tumour size was reduced by more than 75% in 3 patients and by 50-75% in two patients. 3. Diminished visual acuity (one patient), bitemporal hemianopia (2 patients), and oculomotor and trochlear nerve dysfunction (one patient) were restored to normal after the first Parlodel LAR injection. 4. Hypogonadism normalized in 2 patients and improved in one patient, whereas plasma gonadotropins remained low in the 2 postmenopausal women. In one patient with hypothyroidism and hypocorticism, thyroid and adrenal functions normalized. It is concluded that bromocriptine retard (50-100 mg monthly) is a useful alternative for oral treatment of patients with prolactinomas, especially in those patients with compliance problems on oral bromocriptine therapy. |
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Authors:
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J W van 't Verlaat; I Lancranjan; M J Hendriks; R J Croughs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 119 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-10-13 Completed Date: 1988-10-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University Hospital Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
drug therapy*,
radiography,
secretion Adolescent Adult Aged Bromocriptine / administration & dosage*, adverse effects Delayed-Action Preparations Female Humans Male Middle Aged Pituitary Neoplasms / drug therapy*, radiography, secretion Prolactin / secretion* Tomography, X-Ray Computed Visual Acuity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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