| Primary treatment of acute retinal necrosis with oral antiviral therapy. | |
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MedLine Citation:
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PMID: 16996614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To explore the possibility of oral antiviral therapy in lieu of intravenous acyclovir for treating acute retinal necrosis (ARN), a necrotizing retinopathy caused by herpes simplex virus type 1 or 2 or by varicella zoster virus. DESIGN: Retrospective, interventional, small case series. PARTICIPANTS: Four patients (6 eyes). METHODS: Patients were treated with oral antiviral therapy. Medications included valacyclovir (1 g 3 times daily), oral famciclovir (500 mg 3 times daily), and topical and oral corticosteroids. MAIN OUTCOME MEASURES: Improvement of symptoms, including photophobia, blurred vision, ocular discomfort, and floaters; increase in visual acuity; and resolution of vitreitis, retinitis, and retinal vasculitis, where present. RESULTS: Symptoms and visual acuity improved within 2 weeks to 1 month in 3 of 4 patients (75%) treated with oral antiviral medication. One patient required surgical treatment for asymptomatic retinal detachment after 3 weeks of treatment; retinal detachment in the fellow eye was repaired 2 months later. Duration of antiviral therapy ranged from 5 weeks to 3 months. CONCLUSIONS: For 4 patients with relatively indolent cases of ARN, oral antiviral therapy alone was effective in eliminating signs and symptoms of the disease. In particular, oral valacyclovir and famciclovir appeared to be effective, although further study is necessary to determine whether these drugs are as effective as intravenous acyclovir for initial treatment of ARN. |
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Authors:
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Geoffrey G Emerson; Justine R Smith; David J Wilson; James T Rosenbaum; Christina J Flaxel |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-25 |
Journal Detail:
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Title: Ophthalmology Volume: 113 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2006-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 2259-61 Citation Subset: IM |
Affiliation:
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Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Aminopurine
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analogs & derivatives*,
therapeutic use Acyclovir / analogs & derivatives*, therapeutic use Administration, Oral Adult Aged Antiviral Agents / therapeutic use* Cytomegalovirus Retinitis / drug therapy*, virology Drug Therapy, Combination Female Glucocorticoids / therapeutic use Herpes Simplex / drug therapy*, virology Herpes Zoster Ophthalmicus / drug therapy*, virology Herpesvirus 1, Human / isolation & purification Herpesvirus 2, Human / isolation & purification Herpesvirus 3, Human / isolation & purification Humans Male Middle Aged Retinal Necrosis Syndrome, Acute / drug therapy*, virology Retrospective Studies Valine / analogs & derivatives*, therapeutic use Visual Acuity Vitreous Body / virology |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Glucocorticoids; 104227-87-4/famciclovir; 124832-27-5/valacyclovir; 452-06-2/2-Aminopurine; 59277-89-3/Acyclovir; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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