| Primary teeth show less protecting factors against root resorption. | |
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MedLine Citation:
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PMID: 21481035 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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International Journal of Paediatric Dentistry 2011; Background. Physiological root resorption differentiates primary from permanent teeth. The understanding of what protects and regulates root resorption might help to develop therapies to its control. Aim. To verify the presence and distribution of ECRM and the expression of CK14, OPG, TRAP and COX-2 in the periodontal ligament (PDL) of human primary and permanent teeth. Design. Eight primary teeth undergoing physiological or pathological root resorption and 4 permanent teeth were immunohistochemically processed for CK14, TRAP, COX-2 and OPG expression. Results. PDL from primary and permanent teeth showed similar morphological features; however, fewer ECRM clusters and higher immunoreactivity to CK14 were found in primary PDL. In permanent teeth, ECRM were distributed along the entire PDL tissue. Howship's lacunae were found only in primary teeth, associated with the presence of TRAP-positive cells and increase in COX-2 expression. OPG expression in primary PDL was detected in nonresorptive cervical areas and in lacunae showing reparative tissue. It was observed higher expression of OPG in all permanent teeth when compared to primary specimens. Conclusions. It may be concluded that PDL from primary teeth shows less ECRM clusters and lower expression of OPG. These features may be associated with lower protection against root resorption in primary teeth. |
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Authors:
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Mabel M R Cordeiro; Bianca Z Santos; Jessie F Reyes-Carmona; Claudia P Figueiredo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-11 |
Journal Detail:
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Title: International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children Volume: - ISSN: 1365-263X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107511 Medline TA: Int J Paediatr Dent Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd. |
Affiliation:
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Department of Morphological Sciences, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, SC, Brazil PhD Program in Paediatric Dentistry, Federal University of Santa Catarina, Concentration Area Pediatric Dentistry, Florianopolis, SC, Brazil Department of Restorative Sciences, University of Costa Rica, San José, Costa Rica Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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